Branca Bunús to Showcase Gene Delivery Research at ESGCT 2026 in Hamburg
25 October 2026 | Company News
Branca Bunús Ltd (BrB) is pleased to announce that two collaborative research projects with University College Dublin (UCD) will be presented at the upcoming European Society of Gene and Cell Therapy (ESGCT) 2026 Annual Congress, taking place in Hamburg, Germany, from 27–30 October 2026.
The presentations highlight recent advances in lentiviral vector manufacturing, CAR-T applications and polymer-based mRNA delivery.
Dr. Xi Wang will present research on BrB's proprietary BrPERfect® hyperbranched poly(β-amino ester) (HPAE) transfection technology, demonstrating significant improvements in lentiviral manufacturing efficiency compared with conventional PEI-based methods. The study achieved approximately twofold higher lentiviral titres in 3 L bioreactors and demonstrated enhanced CAR-T cytotoxicity under specific experimental conditions.
Irene Reuben will present research investigating the mechanisms influencing polymer-based mRNA delivery compared with lipid nanoparticles. The study identified mRNA condensation, release kinetics and stability as key factors governing delivery performance, with an optimised HPAE formulation achieving a ten-fold improvement in mRNA expression compared with the original polymer system.
These two projects reflect Branca Bunús's continued commitment to scientific innovation and academic–industry collaboration. We gratefully acknowledge the support of I-Form and Research Ireland, and the contributions of our research collaborators at UCD.
Attending ESGCT 2026? We warmly invite you to visit our researchers and discuss their latest findings:
Irene Reuben — Poster P0629: Wednesday, 28 October, 13:30–15:30 Dr. Xi Wang — Poster P0896: Thursday, 29 October, 14:00–16:00
We look forward to connecting with the international gene and cell therapy community in Hamburg!
